Health

Health

Iodine Deficiency

By Ben Fuchs | Pharmacist Ben

Iodine, the 53rd element, so highly regarded for the health of the the thyroid and the functioning of thyroid hormone, was first discovered by French scientists, not in interests of keeping humanity on the road to well-being, but rather interests of keeping Napoleon on his throne. It seems that the diminutive dictator was running out of willow wood, the preferred source of saltpeter (potassium nitrate) which was, at the time, the military’s explosive material of choice and he was looking for another source of combustible substances. As it turned out the coast of France is a rich source of seaweed, from which potassium nitrate (KN) can also be derived. Napoleon charged his scientific experts with the task figuring out a way to efficiently extract KN for the ocean vegetation and within months, the French chemist Bernard Cortois, who has previously been among the first scientists to isolate morphine, had come with a process of pulling out the potassium nitrate and the French military was back in business.

Iodine Deficiency

By LHcheM via Wikimedia Commons

In the process, it was discovered that by adding a little bit extra sulfuric acid to the potassium nitrite extract a purple cloud of vapor would form that over time would crystallize into shiny crystals. When Cortois examined the crystals he realized he had discovered a new element Later on, as the newly produced substance’s properties were elucidated, it was determined to be a fundamental element and it as given the name “iodine”, a derivative for the Greek word for violet.

The important role that iodine plays in human health was first exploited shortly thereafter, in 1820 when the French physician, Jean Lugol created the iodine solution which bears his name. Lugol noticed than when iodine was bonded to a mineral it became water soluble and much easier to work with and these days, so-called Lugol’s Solution considered to be the standard pharmaceutical dosage form for iodine supplementation. Dr. Lugol originally used his solution to treat infectious conditions, he was especially interested in using it to heal tuberculosis, but within 100 years it was being used a s treatment of choice for addressing hypothyroidism. The Nobel Prize winner biochemist Albert Szent-Gyorgyi, who is best known as the discoverer of the Vitamin C molecule was a big fan of iodine. In his biography, Dr. Szent-Gyorgyi calls iodine “the universal medicine”. He actually quotes a little rhyme that he learned in medical school:

“If you don’t know what, where or why, prescribe ye then K and I”, KI standing for potassium iodide, which is the active ingredient ion “Lugol’s Solution”.

These days Dr. Jonathan Wright of the Tahoma Clinic in Washington, talks about using Lugol’s Solution and it’s alternative SSKI, which stands for saturated solution of Potassium Iodide, for purifying drinking water to treating urinary tract infections, to eliminating acne pimples. For UTI’s he recommends adding 10 to 15 drops of SSKI or Lugol’s into a glass of water and drinking it down every 3 or4 hours until the infection is gone and for purifying drinking water he recommends using 2 or 3 drops per glass of unclean water.

Iodine which is a pretty rare element to begin with (of all the essential elements in the earth only selenium is found in lower concentrations than iodine) is easily leached from the soil, which basically means that if you’re not living near an ocean there’s a real good chance you could be iodine deficient. In fact this was such a serious problem a hundred years ago (as the impact of poor farming techniques was beginning to be felt that the occurrence of goiter in Midwest United States, was becoming a significant problem. Thus was born iodized salt, which for the most part eliminated goiter. However, while full blown iodine deficiency may have been eliminated salt iodization but may have a caused the even bigger problem of subclinical iodine deficiency, deficiencies not bad enough to cause blatant symtomology, but bad enough to cause other mis-diagnosed health issues, like hypothyroidism and brain development issues in children.

In my opinion, of the biggest problems when it comes to our understanding of iodine is the crazy medical notion that iodine is simply required for the functioning of the thyroid. Because of this mythology about iodine, the medical community feels like if you don’t have a goiter which is big old swollen thyroid you’re OK, but becomes there are so many different important roles this stuff plays in the body, just because you don’t have a goiter, a swollen thyroid doesn’t necessarily mean you have enough iodine.

For example, besides the well-known connection to thyroid health, iodine is important for mental functioning. According to researchers writing in the American Journal of Clinical Nutrition iodine deficiency can prevent children from attaining quote “their full intellectual potential”. Deficiencies in iodine are considered to be the most preventable cause of brain damage in infants and children and according to the World Health Organization over one third of kids are iodine deficient. Last week, in an article published in the Lancet, researchers in the U.K, found that pregnant women with mild to moderate iodine deficiency during faced an increased risk of giving birth to babies with suboptimal cognitive And, it’s not just kids who are at risk. Again according to the World Health Organization, iodine deficiency in adults can lower adult IQ’s by up to 15 points. Now considering the average adult IQ is around 90 to 100 and 80 is considered dull, losing 15 IQ points can be pretty significant!

[See also: Clearing up the Iodine Confusion]

Nascent Iodine Detoxadine

  • Nascent iodine is the most effective supplemental form of iodine. It is an atomic form of iodine with an incomplete number of electrons, giving it a high electromagnetic charge. The body can absorb and use nascent iodine easily for metabolic and detoxification processes.
  • Detoxadine is nano-colloidal nascent iodine. It is produced with a transformative bio-elemental matrix and, with a glycerin base, is designed to be more gentle on your digestive system than iodine supplements that contain alcohol.
  • It’s created from 300 million-year-old salt deposits located more than 7,000 feet below the earth’s surface. It is an extremely pure nascent iodine that is both concentrated and free of additives and toxins. Each drop is loaded with 650 micrograms iodine and it’s screened for radiation.

Detoxadine Nascent Iodine

Posted by Ben Fuchs in Health

The Importance of Stomach Acid

By Ben Fuchs | Pharmacist Ben

The Importance of Stomach AcidWhat is the importance of stomach acid? According to an article in USA Today, Americans spend almost a billion dollars annually on over-the counter acids and over 13 billion dollars on the prescription varieties. Despite these facts, according to many health care practitioners, deficiencies in stomach acid production is a more significant problem than hyper-secretion.

A little known but vital consideration is the importance of having enough stomach acid. The stomach is supposed to secrete acid to break down food into a soupy consistency called chyme. Acidification of food is required for absorption of key nutrients as well as to stimulate digestive juices from the pancreas and gall bladder.

Regular antacid use can impair both the normal digestive process and is associated with numerous health symptoms such as osteoporosis and hip fractures, malabsorption of critical nutrients like selenium, iron, and vitamins A, E, and the B-complex. And it may actually cause an increase in stomach acid production known as acid rebound.

Determinants of Gastric Acid (Stomach Acid) Secretion

By Adam L. VanWert, Pharm.D., Ph.D. (Own work) [CC BY 3.0 (http://creativecommons.org/licenses/by/3.0)], via Wikimedia Commons

Wikipedia: Gastric Acid
Gastric acid, gastric juice or stomach acid, is a digestive fluid formed in the stomach and is composed of hydrochloric acid (HCl), potassium chloride (KCl) and sodium chloride (NaCl). The acid plays a key role in digestion of proteins, by activating digestive enzymes, and making ingested proteins unravel so that digestive enzymes break down the long chains of amino acids. Gastric acid is produced by cells in the lining of the stomach, which are coupled in feedback systems to increase acid production when needed. Other cells in the stomach produce bicarbonate, a base, to buffer the fluid, ensuring that it does not become too acidic. These cells also produce mucus, which forms a viscous physical barrier to prevent gastric acid from damaging the stomach. The pancreas further produces large amounts of bicarbonate and secretes bicarbonate through the pancreatic duct to the duodenum to completely neutralize any gastric acid that passes further down into the digestive tract.

The main constituent of gastric acid is hydrochloric acid which is produced by parietal cells (also called oxyntic cells) in the gastric glands in the stomach. Its secretion is a complex and relatively energetically expensive process. Parietal cells contain an extensive secretory network (called canaliculi) from which the hydrochloric acid is secreted into the lumen of the stomach. The pH of gastric acid is 1.5 to 3.5[1] in the human stomach lumen, the acidity being maintained by the proton pump H+/K+ ATPase. The parietal cell releases bicarbonate into the bloodstream in the process, which causes a temporary rise of pH in the blood, known as an alkaline tide.

The highly acidic environment in the stomach lumen causes proteins from food to lose their characteristic folded structure (or denature). This exposes the protein’s peptide bonds. The gastric chief cells of the stomach secrete enzymes for protein breakdown (inactive pepsinogen, and in infancy rennin). Hydrochloric acid activates pepsinogen into the enzyme pepsin, which then helps digestion by breaking the bonds linking amino acids, a process known as proteolysis. In addition, many microorganisms have their growth inhibited by such an acidic environment, which is helpful to prevent infection.

Posted by Ben Fuchs in Health

What Really Causes Cancer?

By Ben Fuchs | Pharmacist Ben

What Really Causes Cancer There is no more significant unknown Nobel laureate in the world of health than Dr. Otto Warburg. This brilliant German biochemist, who garnered the prize in 1931 for his work with respiratory (oxygen) enzymes, clearly demonstrated the distinguishing feature of all cancers as being changes in cellular respiration.

What this means is Dr. Warburg discovered that deficiencies in oxygen make cells cancerous. The fundamental property, according to his well researched findings, of cancer tumors are disorders of oxygen utilization. Cancer cells are normal cells that are suffocating.

Two of the best ways to improve cellular oxygen are to take generous quantities of Omega 6 and Omega 3 Essential Fatty Acids, which function as storage and transport forms for oxygen. And, make sure your breathing deeply and powerfully whenever possible.

Otto Heinrich Warburg (October 8, 1883 – August 1, 1970), son of physicist Emil Warburg, was a German physiologist, medical doctor and Nobel laureate. He served as an officer in the elite Ulan (cavalry regiment) during the First World War, and won the Iron Cross (1st Class) for bravery. Warburg was one of the 20th century’s leading biochemists. He won the Nobel Prize of 1931. In total, he was nominated an unprecedented three times for the Nobel prize for three separate achievements. [Wikipedia]

Warburg Hypothesis
The Warburg Theory of Cancer or “Warburg hypothesis” (as distinguished from the Warburg effect) postulates that the driver of tumorigenesis is an insufficient cellular respiration caused by insult to mitochondria. The Warburg Effect describes the observation that cancer cells, and many cells grown in-vitro, exhibit glucose fermentation even when enough oxygen is present to properly respire. In other words, instead of fully respiring in the presence of adequate oxygen, cancer cells ferment. The current popular opinion is that cancer cells ferment glucose while keeping up the same level of respiration that was present before the process of carcinogenesis, and thus the Warburg Effect would be defined as the observation that cancer cells exhibit glycolysis with lactate secretion and mitochondrial respiration even in the presence of oxygen. [Wikipedia]

Posted by Ben Fuchs in Health

The Brain and “Excitotoxins”

By Ben Fuchs | Pharmacist Ben

By now, anyone who’s even slightly interested in health and wellness has heard of the term “excitotoxins”. These health destroying chemical compounds are associated with excitory or stimulatory activity in the brain. Just as there is relaxation and stimulation chemistry in the nervous system outside the brain, there is a similar relaxation and stimulation chemistry that takes place inside the brain. These chemicals are said to be inhibitory for relaxation and excitatory for stimulation.

In the last hundred years or so food manufacturers have figured out that by exciting the brain or activating the brain excitatory neurology, human beings can be fooled into thinking a particular food is the best tasting stuff we’ve ever eaten. If enough of these excitatory chemicals were used, a dog turd would taste like a filet mignon. These excitatory excite the brain; they make the brain happy. The problem is the brain excitatory system is tightly regulated and it’s not supposed to be stimulated by outside chemicals. These kinds of chemicals may be excitatory and may make the brain happy, but they can also ultimately be toxic, thus the term “excito-toxins”.

The brain’s most import excitatory chemical is something called glutamate and the principle artificial excitatory poison or excitotoxin is monosodium glutamate or MSG and if you are dealing with anxiety you should probably be staying away from this stuff. In fact, even if you’re not dealing with anxiety issues you would be wise to avoid MSG. The second excitatory chemical that the brain uses is something called aspartate. And the major source of exogenous aspartate is from Nutrasweet or as it’s known as in the chemical world aspartame. When aspartame is processed in the digestive tract it’s broken down into several components one of which is aspartate. Again, as with glutamate, this means if you’re dealing with anxiety issues you probably want to stay away from aspartame/Nutrasweet.

However, please keep in mind, and this is important to understand: Glutamate and Aspartate are nutrients; you need them and they are most certainly NOT POISONS. They both have critical nutritional value. And they are in no way toxic when consumed in foods and nutritional supplements. Aspartate is important for detoxification of ammonia, it’s involved in the production of DNA and it helps the body make other amino acids, especially lysine without which you can’t make connective tissue. And this is in addition to very important role in brain health. Meat, dairy, sprouts, avocadoes and asparagus are all going to provide you with aspartate and of course many nutritional supplements contain aspartates as part of their amino acid component.

And glutamate is also a key player in detoxification and it has important roles to play in energy metabolism as well as it’s very important role as an excitatory chemical for the brain. Pretty much all high protein foods meat, fish dairy and eggs are going to give you pretty substantial amounts of glutamates.

The problem with both of these substances arises from consumption in food additives that do not have food value or other amino acids to provide a balance. Basically what happens when you take in large amounts of MSG and aspartame is you’re getting large amounts of two very powerful amino acids without the co-factors that are required for the body and nervous systems to safely process these substances. But still these are amino acids without which you cannot live and when uses and consumes carefully they play an important part in keeping the body strong and healthy.

Excitotoxicity

Excitotoxicity is the pathological process by which nerve cells are damaged and killed by excessive stimulation by neurotransmitters such as glutamate and similar substances. This occurs when receptors for the excitatory neurotransmitter glutamate (glutamate receptors) such as the NMDA receptor and AMPA receptor are overactivated by Glutamatergic Storm. Excitotoxins like NMDA and kainic acid which bind to these receptors, as well as pathologically high levels of glutamate, can cause excitotoxicity by allowing high levels of calcium ions (Ca2+) to enter the cell. Ca2+ influx into cells activates a number of enzymes, including phospholipases, endonucleases, and proteases such as calpain. These enzymes go on to damage cell structures such as components of the cytoskeleton, membrane, and DNA.

[From Wikipedia]

The Brain and “Excitotoxins”

By Jaiswal MK, Zech WD, Goos M, Leutbecher C, Ferri A, Zippelius A, Carrì MT, Nau R, Keller BU. via Wikimedia Commons

The Brain and “Excitotoxins”

By Jaiswal MK, Zech WD, Goos M, Leutbecher C, Ferri A, Zippelius A, Carrì MT, Nau R, Keller BU. via Wikimedia Commons

Images: Low Ca2+ buffering and excitotoxicity under physiological stress and pathophysiological conditions in motor neuron (MNs). Low Ca2+ buffering in amyotrophic lateral sclerosis (ALS) vulnerable hypoglossal MNs exposes mitochondria to higher Ca2+ loads compared to highly buffered cells. Under normal physiological conditions, the neurotransmitter opens glutamate, NMDA and AMPA receptor channels, and voltage dependent Ca2+ channels (VDCC) with high glutamate release, which is taken up again by EAAT1 and EAAT2. This results in a small rise in intracellular calcium that can be buffered in the cell. In ALS, a disorder in the glutamate receptor channels leads to high calcium conductivity, resulting in high Ca2+ loads and increased risk for mitochondrial damage. This triggers the mitochondrial production of reactive oxygen species (ROS), which then inhibit glial EAAT2 function. This leads to further increases in the glutamate concentration at the synapse and further rises in postsynaptic calcium levels, contributing to the selective vulnerability of MNs in ALS. [File: CC-BY-2.0 (http://creativecommons.org/licenses/by/2.0), via Wikimedia Commons]

Posted by Ben Fuchs in Health

Fighting Diabetes With Benfotiamine

By Ben Fuchs | Pharmacist Ben

With 100 million plus diabetics and prediabetics in the U.S., and with all the health issues associated with poor blood sugar control, any fresh information about helpful supplements is always welcome news. That’s why the recent study published by the American Society of Nephrology, which focused on a relatively unknown vitamin, benfotiamine, demonstrating its kidney protecting effects against sugar, is so exciting.

Fighting Diabetes With BenfotiamineTechnically referred to as “glycation”, the damaging effect of glucose on the delicate renal circulatory system has long been regarded as one of the more significant health challenges faced by diabetics. According to the researchers from the nephrology department at the University of Heidelberg (Germany) who published the data, the B-vitamin benfotiamine may be a new weapon against glycation of the kidney and other tissues faced by so many unfortunate Americans.

Actually, it’s not so much a new weapon as it’s a recent twist on an old one. Benfotiamine is a fat-soluble version of vitamin B-1, the old standby nutrient for improving blood sugar health that is better known as thiamin. This slight biochemical modification allows benfotiamine to pass into the bloodstream through the digestive tract with much greater facility.

A study published in the International Journal of Clinical Pharmacology in 1996 found that supplementation with benfotiamine resulted in blood levels 5 times higher than thiamine. Fat-solubility also allows benfotiamine to penetrate into cells more effectively. This may give it greater protective and restorative activities than its water-soluble cousin. Benfotiamine is a component of the allithiamines, a naturally occurring class of vitamins found in the allicin group of vegetables which includes garlic, shallots, onions and leeks.

First synthesized by Japanese scientists in 1962, benfotiamine is the considered the most potent of the allithiamines complex. After some initial excitement, when it was discovered that lab mice were able to tolerate over 20 times the amount of benfotiamine than regular vitamin B-1, enthusiasm for this intriguing nutrient faded. It wasn’t until 2003, when Dr. Michael Brownlee of the Albert Einstein College of Medicine published data that showed that benfotiamine blocked several destructive diabetic biochemical pathways that interest was reignited. Since then, attention to benfotiamine has increased dramatically and it’s now possible to obtain in supplemental form from numerous sources.

What’s even more interesting about thiamine’s fat soluble analogue, is that it’s not just diabetics who may benefit. Based on information gleaned from numerous studies and articles, benfotiamine may be helpful for improving numerous health conditions including sciatica, neuropathy, hypertension, accelerated aging, fibromyalgia, and Alzheimer’s disease.

Benfotiamine is readily available in health food stores and via the internet and though there is no consensus on what’s the perfect daily dose, it’s recognized as safe and non-toxic. I would start off with a dose of 300mg a day and increase as needed until adequate benefits (e.g. blood sugar control, pain relief, improved cognition and memory) are achieved. As always, to achieve maximum B-vitamin benefit, when supplementing with one of the B’s, it’s important to include the entire complex in your nutritional supplement protocol.

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Posted by Ben Fuchs in Health